In the present work we have developed and realized a high core-to-cladding diameters ratio active optical fibers operated in a single-mode regime due to specially designed structure containing boron-doped and fluorine-doped rods. The beam quality at the output of the realized fibers was studied by three independent methods: near field investigation, M2 technique and S2 technique. According to the obtained results, the developed approach allows efficient suppression high-order-modes (first of all—LP11 mode) in the core and achieves a diffraction-limited beam at the output of the appropriately bent fiber (suppression of unwanted modes was better than 30 dB). Additionally, it is shown that application of such approach allows for increased bent-resistance of the fundamental mode and realizes polarization-sensitive amplification.