Nature Communications (Oct 2022)
Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment
- Magnus Zethoven,
- Luciano Martelotto,
- Andrew Pattison,
- Blake Bowen,
- Shiva Balachander,
- Aidan Flynn,
- Fernando J. Rossello,
- Annette Hogg,
- Julie A. Miller,
- Zdenek Frysak,
- Sean Grimmond,
- Lauren Fishbein,
- Arthur S. Tischler,
- Anthony J. Gill,
- Rodney J. Hicks,
- Patricia L. M. Dahia,
- Roderick Clifton-Bligh,
- Karel Pacak,
- Richard W. Tothill
Affiliations
- Magnus Zethoven
- Peter MacCallum Cancer Centre
- Luciano Martelotto
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Andrew Pattison
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Blake Bowen
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Shiva Balachander
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Aidan Flynn
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Fernando J. Rossello
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Annette Hogg
- Peter MacCallum Cancer Centre
- Julie A. Miller
- Department of Surgery, Royal Melbourne Hospital
- Zdenek Frysak
- 3rd Department of Internal Medicine – Nephrology, Rheumatology and Endocrinology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc
- Sean Grimmond
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- Lauren Fishbein
- Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, University of Colorado
- Arthur S. Tischler
- Tufts Medical Centre
- Anthony J. Gill
- Sydney Medical School, University of Sydney
- Rodney J. Hicks
- Peter MacCallum Cancer Centre
- Patricia L. M. Dahia
- Div. Hematology and Medical Oncology, Department of Medicine, Mays Cancer Center, University of Texas Health Science Center at San Antonio (UTHSCSA)
- Roderick Clifton-Bligh
- Sydney Medical School, University of Sydney
- Karel Pacak
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Richard W. Tothill
- Centre for Cancer Research and Department of Clinical Pathology, University of Melbourne
- DOI
- https://doi.org/10.1038/s41467-022-34011-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Pheochromocytomas and paragangliomas (PCPG) are rare neuroendocrine tumours. Here, the authors use single-nuclei and bulk-tissue RNA-seq to characterise PCPG tumours and their microenvironments and reveal molecular subtypes as well as expression patterns associated with metastasis.
