The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

Sang-Min Jang; Jenny F. Nathans; Haiqing Fu; Christophe E. Redon; Lisa M. Jenkins; Bhushan L. Thakur; Lőrinc S. Pongor; Adrian M. Baris; Jacob M. Gross; Maura J. OʹNeill; Fred E. Indig; Steven D. Cappell; Mirit I. Aladjem

doi:10.1038/s41467-019-13808-9

Nature Communications (Jan 2020)

The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation

Sang-Min Jang,
Jenny F. Nathans,
Haiqing Fu,
Christophe E. Redon,
Lisa M. Jenkins,
Bhushan L. Thakur,
Lőrinc S. Pongor,
Adrian M. Baris,
Jacob M. Gross,
Maura J. OʹNeill,
Fred E. Indig,
Steven D. Cappell,
Mirit I. Aladjem

Affiliations

Sang-Min Jang: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Jenny F. Nathans: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
Haiqing Fu: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Christophe E. Redon: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Lisa M. Jenkins: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH
Bhushan L. Thakur: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Lőrinc S. Pongor: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Adrian M. Baris: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Jacob M. Gross: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH
Maura J. OʹNeill: Protein Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research
Fred E. Indig: Confocal Imaging Facility, National Institute on Aging, NIH
Steven D. Cappell: Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH
Mirit I. Aladjem: Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH

DOI: https://doi.org/10.1038/s41467-019-13808-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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The spindle assembly checkpoint (SAC) safeguards chromosome segregation by regulating the anaphase promoting complex/cyclosome (APC/C), allowing chromosomes to correctly attach to mitotic spindles. Here the authors reveal a role for Cullin–RING ubiquitin ligase complex 4 (CRL4) in regulating metaphase to anaphase transition via BUB3 degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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