Type 2 leprosy reaction presenting as a monoarthritis post multidrug therapy
Isabela Maria Bernardes Goulart,
Marcela Araujo de Oliveira Santana,
Willian Vargas Tenório da Costa,
Matthew Martin Pavelka,
Bruno de Carvalho Dornelas
Affiliations
Isabela Maria Bernardes Goulart
School of Medicine, Federal University of Uberlândia (UFU), 1720, Pará avenue, Uberlândia, MG, Brazil; Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlândia (UFU), 94, Capricórnio Street, Uberlândia, MG, Brazil; National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberlândia (UFU), 94, Capricórnio Street, Uberlândia, MG, Brazil
Marcela Araujo de Oliveira Santana
National Reference Center for Sanitary Dermatology and Leprosy, School of Medicine, Federal University of Uberlândia (UFU), 94, Capricórnio Street, Uberlândia, MG, Brazil; Corresponding author.
Willian Vargas Tenório da Costa
School of Medicine, Federal University of Uberlândia (UFU), 1720, Pará avenue, Uberlândia, MG, Brazil
Matthew Martin Pavelka
Indiana University School of Medicine, 620 N. Chestnut Street Holmstedt Hall 135, Terre Haute, IN 47809, USA
Bruno de Carvalho Dornelas
School of Medicine, Federal University of Uberlândia (UFU), 1720, Pará avenue, Uberlândia, MG, Brazil
Type 2 leprosy reaction, or erythema nodosum leprosum (ENL), involves a complex interaction between the host's immune system and Mycobacterium leprae. It may occur before, during, or after treatment and have a variable clinical presentation involving different body systems, such as skin, osteoarticular, kidneys, and others. Thus, the differential diagnosis, depending on its clinical presentation, can be broad and challenging. The authors report a case of a severe monoarthritis during a type 2 reaction after the multidrug therapy (MDT) was discharged and the investigation of the differential diagnoses.
