Features of management of children with persistent diarrhea and Candida albicans overgrowth

Abstract

Background: to evaluate the effectiveness of Mutaflor in children from 1 to 4 years of age with a diagnosis of functional gastrointestinal disorders in the form of persistent diarrhea against the background of proven overgrowth of Candida albicans. Materials and methods. The study involved 32 children aged 1 to 4 years with a diagnosis of functional gastrointestinal disorders in the form of persistent diarrhea with proven overgrowth of Candida albicans. Duration of administration of the probiotic agent Mutaflor at a dose of 1 ml of suspension once a day was 15 days. Thirty children completed the follow-up, two patients were excluded from the analysis of results due to non-adherence to treatment protocol. Results. All children had an overgrowth of Candida albicans at baseline. After 15 days of treatment, Candida albicans was detected in the stools of 12 children (40 %), in 11 of them (36.7 %), it was detected in the amount of 104 CFUs, and in one patients (3.3 %) — 103 CFUs indicating that the strain Escherichia coli Nissle 1917 was quite effective for intestinal candidiasis. Conclusions. The use of Mutaflor (Escherichia coli Nissle 1917 probiotic strain) in children with persistent diarrhea against the background of Candida albicans overgrowth contributes to the reduction of diarrhea, colic, abdominal distension, vomiting, episodes of crying/anxiety and poor sleep in children, normalizes intestinal biocenosis.

Keywords

• children
• functional gastrointestinal disorders
• diarrhea
• Candida albicans