Scientific Reports (Jun 2021)

Risk score to stratify miscarriage risk levels in preconception women

  • Xin Hui Choo,
  • Chee Wai Ku,
  • Yin Bun Cheung,
  • Keith M. Godfrey,
  • Yap-Seng Chong,
  • Lynette Pei-Chi Shek,
  • Kok Hian Tan,
  • Thiam Chye Tan,
  • Sadhana Nadarajah,
  • Fabian Kok Peng Yap,
  • Marjorelee T. Colega,
  • Mary Foong-Fong Chong,
  • Shiao-Yng Chan,
  • See Ling Loy,
  • Jerry Kok Yen Chan

DOI
https://doi.org/10.1038/s41598-021-91567-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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Abstract Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.