Frontiers in Immunology (Jan 2022)
Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases
- Xuan Su,
- Xuan Su,
- Peng Yue,
- Peng Yue,
- Jing Kong,
- Jing Kong,
- Xin Xu,
- Xin Xu,
- Yu Zhang,
- Yu Zhang,
- Wenjing Cao,
- Wenjing Cao,
- Yuxin Fan,
- Yuxin Fan,
- Meixiao Liu,
- Meixiao Liu,
- Jingjing Chen,
- Jingjing Chen,
- Aihua Liu,
- Aihua Liu,
- Fukai Bao,
- Fukai Bao
Affiliations
- Xuan Su
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Xuan Su
- Department of Pediatrics, The Affiliated Children Hospital, Kunming Medical University, Kunming, China
- Peng Yue
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Peng Yue
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Jing Kong
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Jing Kong
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Xin Xu
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Xin Xu
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Yu Zhang
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Yu Zhang
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Wenjing Cao
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Wenjing Cao
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Yuxin Fan
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Yuxin Fan
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Meixiao Liu
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Meixiao Liu
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- Jingjing Chen
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Jingjing Chen
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Aihua Liu
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Aihua Liu
- Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming, China
- Fukai Bao
- Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China
- Fukai Bao
- Department of Microbiology and Immunology, Kunming Medical University, Kunming, China
- DOI
- https://doi.org/10.3389/fimmu.2021.792316
- Journal volume & issue
-
Vol. 12
Abstract
Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected.
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