Biomarkers in sepsis

Abstract

Sepsis in children is a global problem causing significant mortality and morbidity. Early identification and prompt treatment is the key to better survival. Sometimes the symptoms are not clear cut and culture sensitivity takes time. Infections lead to synthesis of various biomarkers. These biomarkers can be used as a screening tool to diagnose infections. Some of the markers can help in risk stratification of the disease. Use of biomarkers to monitor drug response is also an important function. The commonly used biomarkers are erythrocyte sedimentation rate, C-reactive protein and Procalcitonin, which have been studied well in children. There are many more biomarkers which are being evaluated.

Keywords

• sepsis
• biomarkers
• c-reactive protein
• procalcitonin