Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

Katja Gemperlein; Demian Dietrich; Michael Kohlstedt; Gregor Zipf; Hubert S. Bernauer; Christoph Wittmann; Silke C. Wenzel; Rolf Müller

doi:10.1038/s41467-019-12025-8

Nature Communications (Sep 2019)

Polyunsaturated fatty acid production by Yarrowia lipolytica employing designed myxobacterial PUFA synthases

Katja Gemperlein,
Demian Dietrich,
Michael Kohlstedt,
Gregor Zipf,
Hubert S. Bernauer,
Christoph Wittmann,
Silke C. Wenzel,
Rolf Müller

Affiliations

Katja Gemperlein: Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland and Helmholtz Centre for Infection Research
Demian Dietrich: Institute for Systems Biotechnology, Saarland University
Michael Kohlstedt: Institute for Systems Biotechnology, Saarland University
Gregor Zipf: ATG:biosynthetics GmbH
Hubert S. Bernauer: ATG:biosynthetics GmbH
Christoph Wittmann: Institute for Systems Biotechnology, Saarland University
Silke C. Wenzel: Department of Pharmacy, Saarland University
Rolf Müller: Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland and Helmholtz Centre for Infection Research

DOI: https://doi.org/10.1038/s41467-019-12025-8
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Sustainable sources are needed to meet the demand for long-chain polyunsaturated fatty acids. Here the authors construct an artificial biosynthetic gene cluster in Y. lipolytica capable of producing a high concentration of PUFAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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