Nature Communications (Sep 2022)

Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies

  • Yan Li,
  • Chen Xu,
  • Bing Wang,
  • Fujiang Xu,
  • Fahan Ma,
  • Yuanyuan Qu,
  • Dongxian Jiang,
  • Kai Li,
  • Jinwen Feng,
  • Sha Tian,
  • Xiaohui Wu,
  • Yunzhi Wang,
  • Yang Liu,
  • Zhaoyu Qin,
  • Yalan Liu,
  • Jing Qin,
  • Qi Song,
  • Xiaolei Zhang,
  • Akesu Sujie,
  • Jie Huang,
  • Tianshu Liu,
  • Kuntang Shen,
  • Jian-Yuan Zhao,
  • Yingyong Hou,
  • Chen Ding

DOI
https://doi.org/10.1038/s41467-022-33282-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 26

Abstract

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The mechanisms of resistance to therapy in gastric cancer remain to be explored. Here, proteomic profiling of 206 tumour tissues from patients treated with chemotherapy and anti-HER2-based therapy results in the identification of four molecular subtypes and the development of prognostic models.