Nature Communications (Sep 2022)
Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals new therapeutic strategies
- Yan Li,
- Chen Xu,
- Bing Wang,
- Fujiang Xu,
- Fahan Ma,
- Yuanyuan Qu,
- Dongxian Jiang,
- Kai Li,
- Jinwen Feng,
- Sha Tian,
- Xiaohui Wu,
- Yunzhi Wang,
- Yang Liu,
- Zhaoyu Qin,
- Yalan Liu,
- Jing Qin,
- Qi Song,
- Xiaolei Zhang,
- Akesu Sujie,
- Jie Huang,
- Tianshu Liu,
- Kuntang Shen,
- Jian-Yuan Zhao,
- Yingyong Hou,
- Chen Ding
Affiliations
- Yan Li
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Chen Xu
- Department of Pathology, Zhongshan Hospital, Fudan University
- Bing Wang
- State Key Laboratory of Cell Differentiation and Regulation, Henan International Joint Laboratory of Pulmonary Fibrosis, Henan center for outstanding overseas scientists of pulmonary fibrosis, College of Life Science, Institute of Biomedical Science, Henan Normal University
- Fujiang Xu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Fahan Ma
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yuanyuan Qu
- Department of Urology, Fudan University Shanghai Cancer Center
- Dongxian Jiang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Kai Li
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Jinwen Feng
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Sha Tian
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Xiaohui Wu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yunzhi Wang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yang Liu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Zhaoyu Qin
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yalan Liu
- Department of Pathology, Zhongshan Hospital, Fudan University
- Jing Qin
- Department of General Surgery, Zhongshan Hospital, Fudan University
- Qi Song
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Xiaolei Zhang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Akesu Sujie
- Department of Pathology, Zhongshan Hospital, Fudan University
- Jie Huang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Tianshu Liu
- Department of Oncology, Zhongshan Hospital, Fudan University
- Kuntang Shen
- Department of General Surgery, Zhongshan Hospital, Fudan University
- Jian-Yuan Zhao
- Institute for Developmental and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Yingyong Hou
- Department of Pathology, Zhongshan Hospital, Fudan University
- Chen Ding
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/s41467-022-33282-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 26
Abstract
The mechanisms of resistance to therapy in gastric cancer remain to be explored. Here, proteomic profiling of 206 tumour tissues from patients treated with chemotherapy and anti-HER2-based therapy results in the identification of four molecular subtypes and the development of prognostic models.
