Nature Communications (Oct 2020)

A compendium of DNA-binding specificities of transcription factors in Pseudomonas syringae

  • Ligang Fan,
  • Tingting Wang,
  • Canfeng Hua,
  • Wenju Sun,
  • Xiaoyu Li,
  • Lucas Grunwald,
  • Jingui Liu,
  • Nan Wu,
  • Xiaolong Shao,
  • Yimeng Yin,
  • Jian Yan,
  • Xin Deng

DOI
https://doi.org/10.1038/s41467-020-18744-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

Read online

The authors set out to identify binding motifs for all 301 transcription factors of a plant pathogenic bacterium, Pseudomonas syringae, using HT-SELEX. They successfully identify binding motifs for 100 transcription factors, infer their binding sites on the genome, and validate the predicted interactions and functions.