A French national breast and thyroid cancer screening programme for survivors of childhood, adolescent and young adult (CAYA) cancers - DeNaCaPST programme
Charlotte Demoor-Goldschmidt,
Delphine Drui,
Isabelle Doutriaux,
Gérard Michel,
Pascal Auquier,
Agnès Dumas,
Claire Berger,
Valérie Bernier,
Sandrine Bohrer,
Pierre-Yves Bondiau,
Bruno Filhon,
Brice Fresneau,
Claire Freycon,
Dinu Stefan,
Sylvie Helfre,
Angela Jackson,
Christine Kerr,
Anne Laprie,
Julie Leseur,
Marc-André Mahé,
Caroline Oudot,
Claire Pluchard,
Stéphanie Proust,
Hélène Sudour-Bonnange,
Céline Vigneron,
Nathalie Lassau,
Martin Schlumberger,
Cécile Faure Conter,
Florent de Vathaire
Affiliations
Charlotte Demoor-Goldschmidt
Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay
Delphine Drui
Department of endocrinology, CHU de Nantes
Isabelle Doutriaux
Department of radiology, Institut de Cancérologie de l’Ouest – René Gauducheau
Gérard Michel
Service d’hématologie et oncologie pédiatrique, Hôpital d’enfants La Timone
Pascal Auquier
Unité de recherche EA 3279, Université Aix-Marseille
Agnès Dumas
Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay
Claire Berger
Claire Berger, hemato-oncology pediatric department, chu nord st Etienne
Valérie Bernier
Department of Radiation Oncology, Institut de Cancérologie de Lorraine
Sandrine Bohrer
Oncology and Hematology Unit, CHU de Saint Denis de La Réunion
Pierre-Yves Bondiau
Department of Radiotherapy, Centre Antoine Lacassagne
Bruno Filhon
Department of Pediatric Hematology and Oncology, Rouen University Hospital
Brice Fresneau
Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay
Claire Freycon
Service d’hématologie et d’oncologie pédiatrique du CHU de Grenoble
Dinu Stefan
Department of Radiation Oncology, Centre François Baclesse
Sylvie Helfre
Department of Radiation Oncology, institut Curie
Angela Jackson
Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay
Christine Kerr
Department of Radiation Oncology, institut du cancer de Montpellier
Anne Laprie
Department of Radiation Oncology, IUCT Oncopole
Julie Leseur
Department of Radiation Oncology, centre Eugène-Marquis
Marc-André Mahé
Department of Radiation Oncology, ICO
Caroline Oudot
Pediatric Oncology Department, Hôpital de la Mère et de l’Enfant
Claire Pluchard
Pediatric Oncology Department, chu Reims, hôpital américain
Stéphanie Proust
Pediatric Oncology Department, chu Angers
Hélène Sudour-Bonnange
Pediatric Oncology Unit, Anti Cancer Center Oscar Lambret
Céline Vigneron
Department of Radiation Oncology, Centre de lutte contre le Cancer Paul Strauss
Nathalie Lassau
Imaging Department, Gustave Roussy Cancer Campus Grand Paris, IR4M UMR8081, Université Paris Sud
Martin Schlumberger
Department of Nuclear Medicine and Endocrine Oncology, Gustave Roussy and Université Paris Saclay
Cécile Faure Conter
Pediatric Oncology Department, Centre Léon-Bérard
Florent de Vathaire
Centre for Research in Epidemiology and Population Health (CESP), Cancer and Radiation team, INSERM U1018, Université Paris-Sud, UVSQ, Université Paris-Saclay
Abstract Background Survival of childhood, adolescent and young adult (CAYA) cancers has increased with progress in the management of the treatments and has reached more than 80% at 5 years. Nevertheless, these survivors are at great risk of second cancers and non-malignant co-morbidities in later life. DeNaCaPST is a non-interventional study whose aim is to organize a national screening for thyroid cancer and breast cancer in survivors of CAYA cancers. It will study the compliance with international recommendations, with the aim, regarding a breast screening programme, of offering for every woman living in France, at equal risk, an equal screening. Method DeNaCaPST trial is coordinated by the INSERM 1018 unit in cooperation with the LEA (French Childhood Cancer Survivor Study for Leukaemia) study’s coordinators, the long term follow up committee and the paediatric radiation committee of the SFCE (French Society of Childhood Cancers). A total of 35 centres spread across metropolitan France and la Reunion will participate. FCCSS (French Childhood Cancer Survivor Study), LEA and central registry will be interrogated to identify eligible patients. To participate, centers agreed to perform a complete “long-term follow-up consultations” according to good clinical practice and the guidelines of the SFCE (French Society of Children Cancers). Discussion As survival has greatly improved in childhood cancers, detection of therapy-related malignancies has become a priority even if new radiation techniques will lead to better protection for organs at risk. International guidelines have been put in place because of the evidence for increased lifetime risk of breast and thyroid cancer. DeNaCaPST is based on these international recommendations but it is important to recognize that they are based on expert consensus opinion and are supported by neither nonrandomized observational studies nor prospective randomized trials in this specific population. Over-diagnosis is a phenomenon inherent in any screening program and therefore such programs must be evaluated.
