Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Amy L. Kenter; Corey T. Watson; Jan-Hendrik Spille

doi:10.3389/fimmu.2021.682589

Frontiers in Immunology (May 2021)

Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire

Amy L. Kenter,
Corey T. Watson,
Jan-Hendrik Spille

Affiliations

Amy L. Kenter: Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL, United States
Corey T. Watson: Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, United States
Jan-Hendrik Spille: Department of Physics, University of Illinois at Chicago, Chicago, IL, United States

DOI: https://doi.org/10.3389/fimmu.2021.682589
Journal volume & issue: Vol. 12

Abstract

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Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are joined to form variable-region exons of expressed immunoglobulins and T cell receptors. This process creates the potential for an organism to respond to large numbers of different pathogens. Here, we consider the possibility that genetic polymorphisms with alterations in a vast array of regulatory elements in the immunoglobulin heavy chain (IgH) locus lead to changes in locus topology and impact immune-repertoire formation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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