Nature Communications (Apr 2019)
Impaired cortico-striatal excitatory transmission triggers epilepsy
- Hiroyuki Miyamoto,
- Tetsuya Tatsukawa,
- Atsushi Shimohata,
- Tetsushi Yamagata,
- Toshimitsu Suzuki,
- Kenji Amano,
- Emi Mazaki,
- Matthieu Raveau,
- Ikuo Ogiwara,
- Atsuko Oba-Asaka,
- Takao K. Hensch,
- Shigeyoshi Itohara,
- Kenji Sakimura,
- Kenta Kobayashi,
- Kazuto Kobayashi,
- Kazuhiro Yamakawa
Affiliations
- Hiroyuki Miyamoto
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Tetsuya Tatsukawa
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Atsushi Shimohata
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Tetsushi Yamagata
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Toshimitsu Suzuki
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Kenji Amano
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Emi Mazaki
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Matthieu Raveau
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Ikuo Ogiwara
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- Atsuko Oba-Asaka
- International Research Center for Neurointelligence (IRCN), The University of Tokyo Institutes for Advanced Study
- Takao K. Hensch
- International Research Center for Neurointelligence (IRCN), The University of Tokyo Institutes for Advanced Study
- Shigeyoshi Itohara
- Laboratory for Behavioral Genetics, RIKEN Center for Brain Science, Wako
- Kenji Sakimura
- Department of Cellular Neurobiology, Brain Research Institute, Niigata University
- Kenta Kobayashi
- Section of Viral Vector Development, National Institute for Physiological Sciences
- Kazuto Kobayashi
- Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine
- Kazuhiro Yamakawa
- Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako
- DOI
- https://doi.org/10.1038/s41467-019-09954-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.
