Nature Communications (Aug 2022)
XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair
- Charlotte Blessing,
- Katja Apelt,
- Diana van den Heuvel,
- Claudia Gonzalez-Leal,
- Magdalena B. Rother,
- Melanie van der Woude,
- Román González-Prieto,
- Adi Yifrach,
- Avital Parnas,
- Rashmi G. Shah,
- Tia Tyrsett Kuo,
- Daphne E. C. Boer,
- Jin Cai,
- Angela Kragten,
- Hyun-Suk Kim,
- Orlando D. Schärer,
- Alfred C. O. Vertegaal,
- Girish M. Shah,
- Sheera Adar,
- Hannes Lans,
- Haico van Attikum,
- Andreas G. Ladurner,
- Martijn S. Luijsterburg
Affiliations
- Charlotte Blessing
- Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich
- Katja Apelt
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Diana van den Heuvel
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Claudia Gonzalez-Leal
- Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich
- Magdalena B. Rother
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Melanie van der Woude
- Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Román González-Prieto
- Department of Cell and Chemical Biology, Leiden University Medical Center (LUMC)
- Adi Yifrach
- Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
- Avital Parnas
- Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
- Rashmi G. Shah
- Laboratory for Skin Cancer Research, CHU-Q: Laval University Hospital Research Centre of Quebec (CHUL site)
- Tia Tyrsett Kuo
- Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich
- Daphne E. C. Boer
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Jin Cai
- Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich
- Angela Kragten
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Hyun-Suk Kim
- Center for Genomic Integrity, Institute for Basic Science
- Orlando D. Schärer
- Center for Genomic Integrity, Institute for Basic Science
- Alfred C. O. Vertegaal
- Department of Cell and Chemical Biology, Leiden University Medical Center (LUMC)
- Girish M. Shah
- Laboratory for Skin Cancer Research, CHU-Q: Laval University Hospital Research Centre of Quebec (CHUL site)
- Sheera Adar
- Department of Microbiology and Molecular Genetics, The Institute for Medical Research Israel-Canada, The Faculty of Medicine, The Hebrew University of Jerusalem
- Hannes Lans
- Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center
- Haico van Attikum
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- Andreas G. Ladurner
- Biomedical Center (BMC), Physiological Chemistry, Faculty of Medicine, LMU Munich
- Martijn S. Luijsterburg
- Department of Human Genetics, Leiden University Medical Center (LUMC)
- DOI
- https://doi.org/10.1038/s41467-022-31820-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Cells employ global genome nucleotide excision repair to repair a broad spectrum of genomic DNA lesions. Here, the authors reveal how chromatin is primed for repair, providing insight into mechanisms of chromatin plasticity during DNA repair.
