Nature Communications (Aug 2018)
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
- Shingo Kozono,
- Yu-Min Lin,
- Hyuk-Soo Seo,
- Benika Pinch,
- Xiaolan Lian,
- Chenxi Qiu,
- Megan K. Herbert,
- Chun-Hau Chen,
- Li Tan,
- Ziang Jeff Gao,
- Walter Massefski,
- Zainab M. Doctor,
- Brian P. Jackson,
- Yuanzhong Chen,
- Sirano Dhe-Paganon,
- Kun Ping Lu,
- Xiao Zhen Zhou
Affiliations
- Shingo Kozono
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Yu-Min Lin
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Hyuk-Soo Seo
- Department of Cancer Biology, Dana Farber Cancer Institute
- Benika Pinch
- Department of Cancer Biology, Dana Farber Cancer Institute
- Xiaolan Lian
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Chenxi Qiu
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Megan K. Herbert
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Chun-Hau Chen
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Li Tan
- Department of Cancer Biology, Dana Farber Cancer Institute
- Ziang Jeff Gao
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Walter Massefski
- Department of Cancer Biology, Dana Farber Cancer Institute
- Zainab M. Doctor
- Department of Cancer Biology, Dana Farber Cancer Institute
- Brian P. Jackson
- Trace Element Analysis Lab, Dartmouth College
- Yuanzhong Chen
- Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, Fujian Medical University
- Sirano Dhe-Paganon
- Department of Cancer Biology, Dana Farber Cancer Institute
- Kun Ping Lu
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- Xiao Zhen Zhou
- Department of Medicine, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-018-05402-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 17
Abstract
Arsenic trioxide and all-trans retinoic acid combination safely cures human acute promyelocytic leukemia. Here, the authors show that this combination has potent anticancer activity in triple negative breast cancer by cooperatively targeting Pin1, a master regulator of oncogenic signaling networks, to eliminate cancer stem cells.
