Frontiers in Oncology (May 2021)
Low miR-214-5p Expression Correlates With Aggressive Subtypes of Pediatric ALCL With Non-Common Histology
- Piero Di Battista,
- Piero Di Battista,
- Federica Lovisa,
- Federica Lovisa,
- Enrico Gaffo,
- Ilaria Gallingani,
- Ilaria Gallingani,
- Carlotta C. Damanti,
- Carlotta C. Damanti,
- Anna Garbin,
- Anna Garbin,
- Lavinia Ferrone,
- Lavinia Ferrone,
- Elisa Carraro,
- Marta Pillon,
- Luca Lo Nigro,
- Rossella Mura,
- Marco Pizzi,
- Vincenza Guzzardo,
- Angelo Paolo Dei Tos,
- Alessandra Biffi,
- Alessandra Biffi,
- Stefania Bortoluzzi,
- Stefania Bortoluzzi,
- Lara Mussolin,
- Lara Mussolin
Affiliations
- Piero Di Battista
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Piero Di Battista
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Federica Lovisa
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Federica Lovisa
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Enrico Gaffo
- Department of Molecular Medicine, University of Padova, Padova, Italy
- Ilaria Gallingani
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Ilaria Gallingani
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Carlotta C. Damanti
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Carlotta C. Damanti
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Anna Garbin
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Anna Garbin
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Lavinia Ferrone
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Lavinia Ferrone
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Elisa Carraro
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Marta Pillon
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Luca Lo Nigro
- Center of Pediatric Hematology Oncology, Azienda Policlinico G. Rodolico – San Marco, Catania, Italy
- Rossella Mura
- Department of Paediatric Haematology-Oncology, Ospedale Pediatrico Microcitemico, Cagliari, Italy
- Marco Pizzi
- Surgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy
- Vincenza Guzzardo
- Surgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy
- Angelo Paolo Dei Tos
- Surgical Pathology and Cytopathology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy
- Alessandra Biffi
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Alessandra Biffi
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- Stefania Bortoluzzi
- Department of Molecular Medicine, University of Padova, Padova, Italy
- Stefania Bortoluzzi
- CRIBI Interdepartmental Research Center for Innovative Biotechnologies (CRIBI), University of Padova, Padova, Italy
- Lara Mussolin
- Division of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, University of Padova, Padova, Italy
- Lara Mussolin
- Istituto di Ricerca Pediatrica Città della Speranza, Padova, Italy
- DOI
- https://doi.org/10.3389/fonc.2021.663221
- Journal volume & issue
-
Vol. 11
Abstract
The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.
Keywords
