Nature Communications (May 2019)

Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions

  • Qian Xiong,
  • Shunxi Dong,
  • Yushuang Chen,
  • Xiaohua Liu,
  • Xiaoming Feng

DOI
https://doi.org/10.1038/s41467-019-09904-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral tetrazoles and devise a dearomative [3+2] annulation reaction of isoquinolines.