Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation
Haokaifeng Wu,
Chuang Li,
Muqaddas Masood,
Zhen Zhang,
Esther González-Almela,
Alvaro Castells-Garcia,
Gaoyang Zou,
Xiaoduo Xu,
Luqin Wang,
Guoqing Zhao,
Shengyong Yu,
Ping Zhu,
Bo Wang,
Dajiang Qin,
Jing Liu
Affiliations
Haokaifeng Wu
CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Chuang Li
School of Life Sciences, University of Science and Technology of China, Hefei 230026, China
Muqaddas Masood
Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China
Zhen Zhang
CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Esther González-Almela
Bioland Laboratory, Guangzhou 510005, China
Alvaro Castells-Garcia
Bioland Laboratory, Guangzhou 510005, China
Gaoyang Zou
Bioland Laboratory, Guangzhou 510005, China
Xiaoduo Xu
School of Life Sciences, University of Science and Technology of China, Hefei 230026, China
Luqin Wang
CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Guoqing Zhao
Bioland Laboratory, Guangzhou 510005, China
Shengyong Yu
CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
Ping Zhu
Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China
Bo Wang
Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China
Dajiang Qin
Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China
Jing Liu
CAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
The static magnetic fields (SMFs) impact on biological systems, induce a variety of biological responses, and have been applied to the clinical treatment of diseases. However, the underlying mechanisms remain largely unclear. In this report, by using human mesenchymal stem cells (MSCs) as a model, we investigated the biological effect of SMFs at a molecular and cellular level. We showed that SMF exposure promotes MSC proliferation and activates the expression of transcriptional factors such as FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) and EGR1 (Early Growth Response 1). In addition, the expression of signal-transduction proteins p-ERK1/2 and p-JNK oscillate periodically with SMF exposure time. Furthermore, we found that the inhibition of the T-type calcium ion channels negates the biological effects of SMFs on MSCs. Together, we revealed that the SMFs regulate T-type calcium ion channels and mediate MSC proliferation via the MAPK signaling pathways.
