Annals of Cardiac Anaesthesia (Jan 2013)

Influence of ethanol-induced pulmonary embolism on hemodynamics in pigs

  • Shinsaku Yata,
  • Masayuki Hashimoto,
  • Toshio Kaminou,
  • Yasufumi Ohuchi,
  • Kimihiko Sugiura,
  • Akira Adachi,
  • Tsuyoshi Kawai,
  • Masayuki Endo,
  • Shohei Takasugi,
  • Shuichi Yamamoto,
  • Kensuke Matsumoto,
  • Mika Kodani,
  • Takashi Ihaya,
  • Makoto Takahashi,
  • Hisao Ito,
  • Toshihide Ogawa

DOI
https://doi.org/10.4103/0971-9784.119164
Journal volume & issue
Vol. 16, no. 4
pp. 245 – 249

Abstract

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Aims and Objectives: Ethanol is widely used for the embolization treatment of vascular malformations, but it can also cause serious complications such us pulmonary hypertension, cardiopulmonary collapse and death. The complications are considered secondary to pulmonary vasospasm and ethanol-induced sludge embolism, etc., We studied the hemodynamic effects of intravenous absolute ethanol injection and ethanol sludge injection in pigs. Materials and Methods: A total of 5 pigs underwent intravenous injection of ex vivo generated ethanol-induced sludge in which residual ethanol was removed (Group S) and 4 pigs underwent intravenous injection of absolute ethanol (Group E). Hemodynamic parameters related to the pulmonary and systemic circulation were compared between the groups. Results: Transient pulmonary hypertension was observed in both groups and the hemodynamic changes were similar in both groups. Conclusions: Sludge can induce transient pulmonary hypertension or cardiopulmonary collapse, without ethanol and may be the mechanism by which ethanol induces its adverse hemodynamic effects.

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