Nature Communications (Jan 2016)
Functional annotation of rare gene aberration drivers of pancreatic cancer
- Yiu Huen Tsang,
- Turgut Dogruluk,
- Philip M. Tedeschi,
- Joanna Wardwell-Ozgo,
- Hengyu Lu,
- Maribel Espitia,
- Nikitha Nair,
- Rosalba Minelli,
- Zechen Chong,
- Fengju Chen,
- Qing Edward Chang,
- Jennifer B. Dennison,
- Armel Dogruluk,
- Min Li,
- Haoqiang Ying,
- Joseph R. Bertino,
- Marie-Claude Gingras,
- Michael Ittmann,
- John Kerrigan,
- Ken Chen,
- Chad J. Creighton,
- Karina Eterovic,
- Gordon B. Mills,
- Kenneth L. Scott
Affiliations
- Yiu Huen Tsang
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Turgut Dogruluk
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Philip M. Tedeschi
- Rutgers Cancer Institute of New Jersey
- Joanna Wardwell-Ozgo
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Hengyu Lu
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Maribel Espitia
- Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
- Nikitha Nair
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Rosalba Minelli
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Zechen Chong
- Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center
- Fengju Chen
- Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
- Qing Edward Chang
- Department of Genomics Medicine, University of Texas M.D. Anderson Cancer Center
- Jennifer B. Dennison
- Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
- Armel Dogruluk
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Min Li
- Department of Medicine, The University of Oklahoma Health Sciences Center
- Haoqiang Ying
- Department of Genomics Medicine, University of Texas M.D. Anderson Cancer Center
- Joseph R. Bertino
- Rutgers Cancer Institute of New Jersey
- Marie-Claude Gingras
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- Michael Ittmann
- Department of Pathology and Immunology, Baylor College of Medicine, One Baylor Plaza
- John Kerrigan
- Rutgers Cancer Institute of New Jersey
- Ken Chen
- Department of Bioinformatics and Computational Biology, University of Texas M.D. Anderson Cancer Center
- Chad J. Creighton
- Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza
- Karina Eterovic
- Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
- Gordon B. Mills
- Department of Systems Biology, University of Texas M.D. Anderson Cancer Center
- Kenneth L. Scott
- Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza
- DOI
- https://doi.org/10.1038/ncomms10500
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Next generation sequencing allows the identification of oncogenic driver genes in pancreatic cancer. Here, in an effort to identify additional causal genes, the authors develop a high throughput in vivoscreen and identify genes that whilst infrequently mutated in pancreatic cancer contribute to tumour formation.
