The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease

Virginia Athanassiadou; Stella Plavoukou; Eirini Grapsa; Maria G. Detsika

doi:10.3390/antiox11122454

Antioxidants (Dec 2022)

The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease

Virginia Athanassiadou,
Stella Plavoukou,
Eirini Grapsa,
Maria G. Detsika

Affiliations

Virginia Athanassiadou: Department of Nephrology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece
Stella Plavoukou: Department of Nephrology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece
Eirini Grapsa: Department of Nephrology, School of Medicine, National and Kapodistrian University of Athens, Aretaieion University Hospital, 11528 Athens, Greece
Maria G. Detsika: 1st Department of Critical Care Medicine & Pulmonary Services, GP Livanos and M Simou Laboratories, Evangelismos Hospital, National and Kapodistrian University of Athens, 10675 Athens, Greece

DOI: https://doi.org/10.3390/antiox11122454
Journal volume & issue: Vol. 11, no. 12
p. 2454

Abstract

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The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.

Published in Antioxidants

ISSN: 2076-3921 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.mdpi.com/journal/antioxidants

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Abstract

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