HbA1c and Platelet indices correlation in type 2 diabetes patients

Abstract

Background: Diabetes mellitus is a metabolic disorder represented by persistent hyperglycemia, which significantly elevates the risk of cardiovascular complications. Platelet dysfunction plays a crucial role in the development of these complications. While HbA1c is a widely employed diagnostic marker for diabetes, its association with platelet indices, reflecting platelet size and activity, in type 2 diabetes patients remains poorly understood. Recent research has increasingly emphasized platelet activation as a key contributing factor to atherothrombotic processes in individuals with diabetes. Aim: Present study aims to find if there is any correlation between platelet indices and HbA1c. Discussion: Hyperglycemia leads to reactive oxygen species and AGEs formation, resulting in endothelial dysfunction. The combination of increased intracellular calcium, decreased cAMP levels, and oxidative stress contributes to platelet hyperactivity. Endothelial dysfunction exacerbates this hyperactivity and manifests as an increase in platelet size and alterations in platelet indices. Conclusion: Our research findings indicate that diabetes mellitus exhibits larger and more active platelets, resulting in an elevated thrombogenic potential. It also revealed a direct and positive correlation between platelet indices and HbA1c levels.

Keywords

• hba1c
• mpv
• pdw
• p-lcr
• platelet indices