Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers

Nan Ouyang; Lei Hong; Yuanshuai Zhou; Jingzhong Zhang; Shaheryar Shafi; Jinlin Pan; Rongchuan Zhao; Ying Yang; Wenya Hou

Polymer Testing (Nov 2022)

Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers

Nan Ouyang,
Lei Hong,
Yuanshuai Zhou,
Jingzhong Zhang,
Shaheryar Shafi,
Jinlin Pan,
Rongchuan Zhao,
Ying Yang,
Wenya Hou

Affiliations

Nan Ouyang: School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Lei Hong: School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Suzhou Science & Technology Town Hospital, Suzhou, 215153, China
Yuanshuai Zhou: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China
Jingzhong Zhang: Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China
Shaheryar Shafi: School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Jinlin Pan: School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Rongchuan Zhao: School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China
Ying Yang: The People's Hospital of Suzhou New District, Suzhou, China; Corresponding author.
Wenya Hou: Shenzhen University General Hospital, Guangdong Key Laboratory for Genome Stability & Disease Prevention, Shenzhen University School of Medicine, Shenzhen, Guangdong, 518060, China; Corresponding author.

Journal volume & issue: Vol. 115
p. 107746

Abstract

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Fluorescent sensors developed based on nano-materials have penetrated into cancer medical sensing research due to their unique properties, such as high sensitivity, high specificity. The number of cancer patients has continued to rise in recent years, and the limitations of traditional cancer diagnosis methods can no longer meet the demand for accurate early cancer screening. Accurate identification of cancer bio-macromolecular markers can significantly improve early diagnosis and follow-up treatment. To this end, we provide an overview of the properties and uses of different nano-materials and detail the principles and functions of fluorescent nano-biosensor detection for different cancer bio-macromolecular markers. In addition, the prospects and challenges of translating this convenient and visual diagnostic method into the clinical application are discussed.

Published in Polymer Testing

ISSN: 0142-9418 (Print); 1873-2348 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Polymers and polymer manufacture
Website: https://www.journals.elsevier.com/polymer-testing

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