Química Nova (Jan 2009)

Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (Annonaceae)

  • Emmanoel Vilaça Costa,
  • Maria Lúcia Belém Pinheiro,
  • Jefferson Rocha de Andrade Silva,
  • Beatriz Helena Lameiro de Noronha Sales Maia,
  • Marta Cristina Teixeira Duarte,
  • Ana Cláudia Fernandes Amaral,
  • Gérzia Maria de Carvalho Machado,
  • Leonor Laura Leon

DOI
https://doi.org/10.1590/S0100-40422009000100015
Journal volume & issue
Vol. 32, no. 1
pp. 78 – 81

Abstract

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bicyclogermacrene (35.12%), (E)-caryophyllene (14.19%) and α-copaene (8.19%). The antimicrobial and antileishmanial activities were investigated. The oil showed potent antimicrobial activity against Candida albicans and Rhodococcus equi. The oil also showed significant antileishmanial activity, giving the best results against Leishmania guyanensis. A preliminary cytotoxicity assay for this oil was carried out on hamster and mice (Balb/c) peritoneal macrophages. The results obtained were similar to pentamidine and considered not to be cytotoxic to macrophages.

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