BCG DISSEMINATION IN 40 PATIENTS AND THE REVIEW OF "LEUKOCYTE MYCOBACTERIUM DEFECT" IN ONE PATIENT

Abstract

We have reviewed the medical records of 40 patients with disseminated (Bacille Calmette-Guerin) BCG from 1996 to 1999 in the Immunology Department of the Children Hospital, Medical Center, Tehran university. These patients are divided in to 3 groups: 1. Patients who had disseminated (Bacille Calmette-Guerin) BCG after vaccination and their diagnosis was chronic granulomatous disease. 2. Patients who had disseminated (Bacille Calmette-Guerin) BCG and were diagnosed as having cell mediated immunodeficiency. 3. Patients whose Nitroblue Tetrazulium and CMI were around normal, but they could not kill intracellular mycobacterium, because of confirmed deficiency of interferon-gam ma receptor and IL12 receptor. Interferon-gamma receptor or CD'119 was checked in 6 patients. In one patient interferon-gamma receptor deficiency was confirmed by flowcytometric analysis. In other patients, this marker was around normal, but presumably they had IL12 receptor deficiency, which we were unable to detect in our laboratory. In some patients this marker should be checked after preparation of more laboratory facilities.

Keywords

• Interferon-Gamma
• Receptor
• Interleukin-12 Receptor Deficiency
• Leukocyte Mycobacterium Defect