THE MECHANISMS OF ATROPHIC COLPITIS FORMATION IN WOMEN IN POST-REPRODUCTIVE PERIOD

Abstract

Purpose: too analyse a set of parameters of fatty acid composition of vaginal tissue as well as vitamin D, calcium and phosphorus content in blood of women with atrophic colpitis in the post-reproductive period.Materials and methods: we have examined vaginal tissue and blood of 35 women (age 51 ± 2.8 years), having objective signs of moderate atrophy. Control group included 35 women (age 48 ± 3.6 years) lacking any pathological urogenital symptomatics. The fatty acid composition of vaginal tissue, and also the levels of vitamin D, calcium and phosphorus in blood have been analysed.Results: in atrophic colpitis the content of higher unsaturated fatty acids increases in vaginal tissue. At the same time the stable level of phosphorus and calcium metabolism is maintained in the blood.Summary: in atrophic colpitis a pathogenic chain forms associated with the changes in direction of different metabolic pathways, the disruption of cell transport systems functioning. This leads to different systemic alterations on the cellular level, which can be related not only to steroidogenesis decrease, but also to the disruption of hormone-receptor transmission in differential signaling systems.

Keywords

• atrophic colpitis
• metabolism