Nature Communications (Jul 2020)

The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit

  • Andrew P. Patton,
  • Mathew D. Edwards,
  • Nicola J. Smyllie,
  • Ryan Hamnett,
  • Johanna E. Chesham,
  • Marco Brancaccio,
  • Elizabeth S. Maywood,
  • Michael H. Hastings

DOI
https://doi.org/10.1038/s41467-020-17110-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al. show that cells expressing VIP or its receptor VPAC2 together determine these emergent properties of the SCN.