Peculiarities of a humoral immune response in coronavirus infection (COVID-19)

Abstract

We reviewed scientific data published during the recent 12 months about peculiarities of a humoral immune response in coronavirus infection (COVID-19). We also examined the concentration of immunoglobulin G against SARS-CoV-2 in 65 people in the Diagnostic Center “MeDIS” in 2020 with the diagnostic titer of specific antibodies. We established that in 3 months after primary examination of serum 60 % of examined patients presented high titers of IgG against SARS-CoV-2 (seropositivity rate > 7) in ELISA test. The highest level of IgG against SARS-CoV-2 in 3 months after the primary examination was revealed in those with a high initial level of antibodies against this virus.

Keywords

• coronavirus, covid-19, immunoglobulin, enzyme-linked immunosorbent assay