Nature Communications (Jul 2021)
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
- Corvin Walter,
- Adinarayana Marada,
- Tamara Suhm,
- Ralf Ernsberger,
- Vera Muders,
- Cansu Kücükköse,
- Pablo Sánchez-Martín,
- Zehan Hu,
- Abhishek Aich,
- Stefan Loroch,
- Fiorella Andrea Solari,
- Daniel Poveda-Huertes,
- Alexandra Schwierzok,
- Henrike Pommerening,
- Stanka Matic,
- Jan Brix,
- Albert Sickmann,
- Claudine Kraft,
- Jörn Dengjel,
- Sven Dennerlein,
- Tilman Brummer,
- F.-Nora Vögtle,
- Chris Meisinger
Affiliations
- Corvin Walter
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Adinarayana Marada
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Tamara Suhm
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Ralf Ernsberger
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Vera Muders
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Cansu Kücükköse
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Pablo Sánchez-Martín
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Zehan Hu
- Department of Biology, University of Fribourg
- Abhishek Aich
- Department of Cellular Biochemistry, University Medical Center Göttingen
- Stefan Loroch
- Leibniz Institut für Analytische Wissenschaften - ISAS - e.V.
- Fiorella Andrea Solari
- Leibniz Institut für Analytische Wissenschaften - ISAS - e.V.
- Daniel Poveda-Huertes
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Alexandra Schwierzok
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Henrike Pommerening
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Stanka Matic
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Jan Brix
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Albert Sickmann
- Leibniz Institut für Analytische Wissenschaften - ISAS - e.V.
- Claudine Kraft
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Jörn Dengjel
- Department of Biology, University of Fribourg
- Sven Dennerlein
- Department of Cellular Biochemistry, University Medical Center Göttingen
- Tilman Brummer
- Institute of Molecular Medicine, ZBMZ, Faculty of Medicine, University of Freiburg
- F.-Nora Vögtle
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- Chris Meisinger
- Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-021-24426-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Mitochondrial protein import is mediated by the translocase of the outer membrane (TOM), through which nearly all precursors traverse. Here, the authors perform global in vitro kinome profiling and by this identify that DYRK1A phosphorylates TOM70 and promotes import.
