Higher Adiponectin Levels in Children and Adolescents with T1D Probably Contribute to the Osteopenic Phenotype through the RANKL/OPG System Activation
Charalampos Tsentidis,
Dimitrios Gourgiotis,
Lydia Kossiva,
Antonios Marmarinos,
Artemis Doulgeraki,
Kyriaki Karavanaki
Affiliations
Charalampos Tsentidis
Diabetes Clinic, 2nd Department of Pediatrics, Athens University Medical School, “P&A Kyriakou” Children’s Hospital, 11527 Athens, Greece
Dimitrios Gourgiotis
Laboratory of Clinical Biochemistry—Molecular Diagnostics, 2nd Department of Pediatrics, Athens University Medical School, “P&A Kyriakou” Children’s Hospital, 11527 Athens, Greece
Lydia Kossiva
Diabetes Clinic, 2nd Department of Pediatrics, Athens University Medical School, “P&A Kyriakou” Children’s Hospital, 11527 Athens, Greece
Antonios Marmarinos
Laboratory of Clinical Biochemistry—Molecular Diagnostics, 2nd Department of Pediatrics, Athens University Medical School, “P&A Kyriakou” Children’s Hospital, 11527 Athens, Greece
Artemis Doulgeraki
Department of Bone and Mineral Metabolism, Institute of Child Health, “Aghia Sophia” Children’s Hospital, 11527 Athens, Greece
Kyriaki Karavanaki
Diabetes Clinic, 2nd Department of Pediatrics, Athens University Medical School, “P&A Kyriakou” Children’s Hospital, 11527 Athens, Greece
Background: Diabetes mellitus is an increasing global health emergency, with serious complications (including osteoporosis). Leptin and adiponectin are among the least-investigated possible contributing factors of T1D low bone mass. Methods: In this case-control cross-sectional analysis, we evaluated 40 pairs of T1D children and adolescents and controls. We evaluated body diameters and skinfolds, leptin, adiponectin, lipids and lipoproteins, bone metabolic markers and DXA parameters of BMD and fat percentage. Results: Leptin levels were comparable between groups and correlated well with body mass parameters. Adiponectin levels were found to be higher in the patient group and correlated with higher levels of HbA1c, triglycerides and s-RANKL. Conclusions: In this study, leptin levels were no different, but adiponectin levels were found to be higher in children and adolescents with T1D and correlated with diabetic metabolic derangement indices and s-RANKL in the patient group. Adiponectin can be considered a surrogate marker of T1D in young patients’ metabolic status and probably contributes to the diabetic low bone mass phenotype via activation of the RANKL/OPG metabolic pathway.
