Nature Communications (Apr 2023)
Role of TMEM100 in mechanically insensitive nociceptor un-silencing
- Timo A. Nees,
- Na Wang,
- Pavel Adamek,
- Nadja Zeitzschel,
- Clement Verkest,
- Carmen La Porta,
- Irina Schaefer,
- Julie Virnich,
- Selin Balkaya,
- Vincenzo Prato,
- Chiara Morelli,
- Valerie Begay,
- Young Jae Lee,
- Anke Tappe-Theodor,
- Gary R. Lewin,
- Paul A. Heppenstall,
- Francisco J. Taberner,
- Stefan G. Lechner
Affiliations
- Timo A. Nees
- Institute of Pharmacology, Heidelberg University
- Na Wang
- Institute of Pathophysiology, Yan’an University
- Pavel Adamek
- Department of Anesthesiology, University Medical Center Hamburg-Eppendorf
- Nadja Zeitzschel
- Department of Anesthesiology, University Medical Center Hamburg-Eppendorf
- Clement Verkest
- Department of Anesthesiology, University Medical Center Hamburg-Eppendorf
- Carmen La Porta
- Institute of Pharmacology, Heidelberg University
- Irina Schaefer
- Institute of Pharmacology, Heidelberg University
- Julie Virnich
- Department of Anesthesiology, University Medical Center Hamburg-Eppendorf
- Selin Balkaya
- Department of Anesthesiology, University Medical Center Hamburg-Eppendorf
- Vincenzo Prato
- Institute of Pharmacology, Heidelberg University
- Chiara Morelli
- SISSA: Scuola Internazionale Superiore di Studi Avanzati
- Valerie Begay
- Department of Neuroscience, Max Delbrück Center for Molecular Medicine
- Young Jae Lee
- Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine
- Anke Tappe-Theodor
- Institute of Pharmacology, Heidelberg University
- Gary R. Lewin
- Department of Neuroscience, Max Delbrück Center for Molecular Medicine
- Paul A. Heppenstall
- SISSA: Scuola Internazionale Superiore di Studi Avanzati
- Francisco J. Taberner
- Institute of Pharmacology, Heidelberg University
- Stefan G. Lechner
- Institute of Pharmacology, Heidelberg University
- DOI
- https://doi.org/10.1038/s41467-023-37602-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 17
Abstract
Silent nociceptors remained enigmatic ever since they were first described decades ago. Here, Nees. et al. show that inflammation-induced upregulation of TMEM100 unsilences silent nociceptors, which triggers secondary mechanical pain hypersensitivity.
