Archives of Epilepsy (Dec 2015)

Epilepsi Hastalarında Lamotrijin Deneyimi

  • Levent ÖCEK,
  • İrem Fatma ULUDAĞ,
  • Derya GÜNER,
  • Yaşar ZORLU

DOI
https://doi.org/10.5505/epilepsi.2015.16362
Journal volume & issue
Vol. 21, no. 3
pp. 128 – 132

Abstract

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Objectives:The aim of the present study was to investigate the effect and side effects of lamotrigine (LTG) on seizures.Methods:Epilepsy outpatient clinic records for 416 patients who had been monitored for at least 6 months were studied retrospectively. Age, sex, seizure type, number of seizures, additional drugs used in treatment, duration of treatment, and drug side effects were analyzed.Results:Of the 416 patients, 244 (58.7%) were female, and 162 were male (41.3%). Mean age was 33.2±10.7. Monthly seizure rates were reduced 67.3% with LTG treatment, and 328 patients (78.8%) were still receiving treatment, while 88 (21.2%) had stopped usage due to side effects or for other reasons. Of these side effects, dizziness (5.5%) and rash (4.3%) were the most common. Pregnancy occurred in 18 patients on LTG treatment, and no malformation was detected at birth.Conclusion:In refractory epileptic patients, LTG has a high activity level and an acceptable side effect profile.

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