Facile synthesis of core–shell structured magnetic Fe3O4@SiO2@Au molecularly imprinted polymers for high effective extraction and determination of 4-methylmethcathinone in human urine samples
Wu Fangsheng,
Zhang Zihua,
Liu Wei,
Liu Yuan,
Chen Xiujuan,
Liao Pingyong,
Han Qiaoying,
Song Lun,
Chen Hong,
Liu Wenbin
Affiliations
Wu Fangsheng
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Zhang Zihua
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Liu Wei
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Liu Yuan
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Chen Xiujuan
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Liao Pingyong
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Han Qiaoying
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Song Lun
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Chen Hong
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
Liu Wenbin
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, 803 Zhongshan North 1st Road, Shanghai, 200083, China
In this study, a novel material of core–shell structured magnetic molecularly imprinted polymers (Fe3O4@SiO2@Au (FSA)-MIPs) was successfully prepared for the rapid and selective determination of 4-methylmethcathinone (mephedrone, 4-MMC). The adsorption capacity of FSA-MIPs is 34.7 mg·g−1 at 308 K, which is significantly higher than magnetic non-imprinted polymers profiting from the imprinting effect. The FSA-MIPs have a short equilibrium (20 min) and could be reused more than six times. Moreover, the selectivity coefficients of FSA-MIPs for 4-MMC, 3,4-dimethylmethcathinone, butylone, 4-ethylmethcathinone, acetylfentanyl, and methylene blue are 4.01, 5.65, 7.62, 12.30, and 20.87 respectively, further indicating the markedly enhanced binding selectivity of FSA-MIPs. As an adsorbent, the FSA-MIPs were successfully applied for effective extraction of 4-MMC in three human urine samples with the recovery rates ranging from 85.5–92.6%. The results confirmed that the FSA-MIPs have good prospects in the extraction and separation of synthetic cathinones, which is suitable for further application in the criminal sciences field.
