Nature Communications (Jun 2017)
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
- Ghislaine Scelo,
- Mark P. Purdue,
- Kevin M. Brown,
- Mattias Johansson,
- Zhaoming Wang,
- Jeanette E. Eckel-Passow,
- Yuanqing Ye,
- Jonathan N. Hofmann,
- Jiyeon Choi,
- Matthieu Foll,
- Valerie Gaborieau,
- Mitchell J. Machiela,
- Leandro M. Colli,
- Peng Li,
- Joshua N. Sampson,
- Behnoush Abedi-Ardekani,
- Celine Besse,
- Helene Blanche,
- Anne Boland,
- Laurie Burdette,
- Amelie Chabrier,
- Geoffroy Durand,
- Florence Le Calvez-Kelm,
- Egor Prokhortchouk,
- Nivonirina Robinot,
- Konstantin G. Skryabin,
- Magdalena B. Wozniak,
- Meredith Yeager,
- Gordana Basta-Jovanovic,
- Zoran Dzamic,
- Lenka Foretova,
- Ivana Holcatova,
- Vladimir Janout,
- Dana Mates,
- Anush Mukeriya,
- Stefan Rascu,
- David Zaridze,
- Vladimir Bencko,
- Cezary Cybulski,
- Eleonora Fabianova,
- Viorel Jinga,
- Jolanta Lissowska,
- Jan Lubinski,
- Marie Navratilova,
- Peter Rudnai,
- Neonila Szeszenia-Dabrowska,
- Simone Benhamou,
- Geraldine Cancel-Tassin,
- Olivier Cussenot,
- Laura Baglietto,
- Heiner Boeing,
- Kay-Tee Khaw,
- Elisabete Weiderpass,
- Borje Ljungberg,
- Raviprakash T. Sitaram,
- Fiona Bruinsma,
- Susan J. Jordan,
- Gianluca Severi,
- Ingrid Winship,
- Kristian Hveem,
- Lars J. Vatten,
- Tony Fletcher,
- Kvetoslava Koppova,
- Susanna C. Larsson,
- Alicja Wolk,
- Rosamonde E. Banks,
- Peter J. Selby,
- Douglas F. Easton,
- Paul Pharoah,
- Gabriella Andreotti,
- Laura E. Beane Freeman,
- Stella Koutros,
- Demetrius Albanes,
- Satu Männistö,
- Stephanie Weinstein,
- Peter E. Clark,
- Todd L. Edwards,
- Loren Lipworth,
- Susan M. Gapstur,
- Victoria L. Stevens,
- Hallie Carol,
- Matthew L. Freedman,
- Mark M. Pomerantz,
- Eunyoung Cho,
- Peter Kraft,
- Mark A. Preston,
- Kathryn M. Wilson,
- J. Michael Gaziano,
- Howard D. Sesso,
- Amanda Black,
- Neal D. Freedman,
- Wen-Yi Huang,
- John G. Anema,
- Richard J. Kahnoski,
- Brian R. Lane,
- Sabrina L. Noyes,
- David Petillo,
- Bin Tean Teh,
- Ulrike Peters,
- Emily White,
- Garnet L. Anderson,
- Lisa Johnson,
- Juhua Luo,
- Julie Buring,
- I-Min Lee,
- Wong-Ho Chow,
- Lee E. Moore,
- Christopher Wood,
- Timothy Eisen,
- Marc Henrion,
- James Larkin,
- Poulami Barman,
- Bradley C. Leibovich,
- Toni K. Choueiri,
- G. Mark Lathrop,
- Nathaniel Rothman,
- Jean-Francois Deleuze,
- James D. McKay,
- Alexander S. Parker,
- Xifeng Wu,
- Richard S. Houlston,
- Paul Brennan,
- Stephen J. Chanock
Affiliations
- Ghislaine Scelo
- International Agency for Research on Cancer (IARC)
- Mark P. Purdue
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Kevin M. Brown
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Mattias Johansson
- International Agency for Research on Cancer (IARC)
- Zhaoming Wang
- Department of Computational Biology, St Jude Children's Research Hospital
- Jeanette E. Eckel-Passow
- Department of Health Sciences Research, Mayo Clinic
- Yuanqing Ye
- Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center
- Jonathan N. Hofmann
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Jiyeon Choi
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Matthieu Foll
- International Agency for Research on Cancer (IARC)
- Valerie Gaborieau
- International Agency for Research on Cancer (IARC)
- Mitchell J. Machiela
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Leandro M. Colli
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Peng Li
- International Agency for Research on Cancer (IARC)
- Joshua N. Sampson
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Behnoush Abedi-Ardekani
- International Agency for Research on Cancer (IARC)
- Celine Besse
- Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
- Helene Blanche
- Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain
- Anne Boland
- Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
- Laurie Burdette
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Amelie Chabrier
- International Agency for Research on Cancer (IARC)
- Geoffroy Durand
- International Agency for Research on Cancer (IARC)
- Florence Le Calvez-Kelm
- International Agency for Research on Cancer (IARC)
- Egor Prokhortchouk
- Center ‘Bioengineering’ of the Russian Academy of Sciences
- Nivonirina Robinot
- International Agency for Research on Cancer (IARC)
- Konstantin G. Skryabin
- Center ‘Bioengineering’ of the Russian Academy of Sciences
- Magdalena B. Wozniak
- International Agency for Research on Cancer (IARC)
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Gordana Basta-Jovanovic
- Institute of Pathology, School of Medicine, University of Belgrade
- Zoran Dzamic
- Clinical Center of Serbia (KCS), Clinic of Urology, University of Belgrade-Faculty of Medicine
- Lenka Foretova
- Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute
- Ivana Holcatova
- 2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University
- Vladimir Janout
- Department of Preventive Medicine, Faculty of Medicine, Palacky University
- Dana Mates
- National Institute of Public Health
- Anush Mukeriya
- Russian N.N. Blokhin Cancer Research Centre
- Stefan Rascu
- Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital
- David Zaridze
- Russian N.N. Blokhin Cancer Research Centre
- Vladimir Bencko
- First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University
- Cezary Cybulski
- Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University
- Eleonora Fabianova
- Regional Authority of Public Health in Banska Bystrica
- Viorel Jinga
- Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital
- Jolanta Lissowska
- The M Sklodowska-Curie Cancer Center and Institute of Oncology
- Jan Lubinski
- Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University
- Marie Navratilova
- Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute
- Peter Rudnai
- National Public Health Center, National Directorate of Environmental Health
- Neonila Szeszenia-Dabrowska
- Department of Epidemiology, Institute of Occupational Medicine
- Simone Benhamou
- Université Paris Diderot, INSERM, Unité Variabilité Génétique et Maladies Humaines
- Geraldine Cancel-Tassin
- CeRePP, Tenon Hospital
- Olivier Cussenot
- CeRePP, Tenon Hospital
- Laura Baglietto
- Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy
- Heiner Boeing
- Department of Epidemiology, German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke
- Kay-Tee Khaw
- Department of Public Health and Primary Care, University of Cambridge
- Elisabete Weiderpass
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway
- Borje Ljungberg
- Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University
- Raviprakash T. Sitaram
- Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University
- Fiona Bruinsma
- Cancer Epidemiology Centre, Cancer Council Victoria
- Susan J. Jordan
- QIMR Berghofer Medical Research Institute
- Gianluca Severi
- Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy
- Ingrid Winship
- Department of Medicine, The University of Melbourne
- Kristian Hveem
- Department of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology
- Lars J. Vatten
- Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology
- Tony Fletcher
- London School of Hygiene and Tropical Medicine, University of London
- Kvetoslava Koppova
- Regional Authority of Public Health in Banska Bystrica
- Susanna C. Larsson
- Institute of Environmental Medicine, Karolinska Institutet
- Alicja Wolk
- Institute of Environmental Medicine, Karolinska Institutet
- Rosamonde E. Banks
- Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital
- Peter J. Selby
- Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital
- Douglas F. Easton
- Department of Public Health and Primary Care, University of Cambridge
- Paul Pharoah
- Department of Public Health and Primary Care, University of Cambridge
- Gabriella Andreotti
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Laura E. Beane Freeman
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Stella Koutros
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Satu Männistö
- Department of Health, National Institute for Health and Welfare
- Stephanie Weinstein
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Peter E. Clark
- Department of Urology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center
- Todd L. Edwards
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center
- Loren Lipworth
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center
- Susan M. Gapstur
- American Cancer Society
- Victoria L. Stevens
- American Cancer Society
- Hallie Carol
- Dana-Farber Cancer Institute
- Matthew L. Freedman
- Dana-Farber Cancer Institute
- Mark M. Pomerantz
- Dana-Farber Cancer Institute
- Eunyoung Cho
- Warren Alpert Medical School of Brown University
- Peter Kraft
- Harvard T.H. Chan School of Public Health
- Mark A. Preston
- Brigham and Women's Hospital and VA Boston
- Kathryn M. Wilson
- Harvard T.H. Chan School of Public Health
- J. Michael Gaziano
- Brigham and Women's Hospital and VA Boston
- Howard D. Sesso
- Harvard T.H. Chan School of Public Health
- Amanda Black
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Neal D. Freedman
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Wen-Yi Huang
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- John G. Anema
- Division of Urology, Spectrum Health
- Richard J. Kahnoski
- Division of Urology, Spectrum Health
- Brian R. Lane
- Division of Urology, Spectrum Health
- Sabrina L. Noyes
- Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
- David Petillo
- Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
- Bin Tean Teh
- Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology
- Ulrike Peters
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Emily White
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Garnet L. Anderson
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Lisa Johnson
- Cancer Prevention Program, Fred Hutchinson Cancer Research Center
- Juhua Luo
- Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington
- Julie Buring
- Harvard T.H. Chan School of Public Health
- I-Min Lee
- Harvard T.H. Chan School of Public Health
- Wong-Ho Chow
- Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center
- Lee E. Moore
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Christopher Wood
- Department of Urology, The University of Texas M.D. Anderson Cancer Center
- Timothy Eisen
- Department of Oncology, Cambridge University Hospitals NHS Foundation Trust
- Marc Henrion
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- James Larkin
- Medical Oncology, Royal Marsden NHS Foundation Trust
- Poulami Barman
- Department of Health Sciences Research, Mayo Clinic
- Bradley C. Leibovich
- Department of Urology, Mayo Medical School and Mayo Clinic
- Toni K. Choueiri
- Dana-Farber Cancer Institute
- G. Mark Lathrop
- McGill University and Genome Quebec Innovation Centre
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- Jean-Francois Deleuze
- Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
- James D. McKay
- International Agency for Research on Cancer (IARC)
- Alexander S. Parker
- Department of Health Sciences Research, Mayo Clinic
- Xifeng Wu
- Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Paul Brennan
- International Agency for Research on Cancer (IARC)
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, Department Health and Human Services, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/ncomms15724
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 9
Abstract
Risk for renal cell carcinoma (RCC) is higher when there are first-degree family members with the disease. Here, Scelo and colleagues perform a genome-wide association meta-analysis and new genome-wide scan to identify seven new loci with significant RCC association.
