Molecules (Nov 2022)

Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

  • Mary M. LeClair,
  • Zacharie A. Maw,
  • Alyssa L. Grunwald,
  • Joshua R. Kelly,
  • Bradley A. Haltli,
  • Russell G. Kerr,
  • Christopher Cartmell

DOI
https://doi.org/10.3390/molecules27227794
Journal volume & issue
Vol. 27, no. 22
p. 7794

Abstract

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Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.

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