Nature Communications (May 2021)
Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer
- Fei Tian,
- Shaohua Zhang,
- Chao Liu,
- Ziwei Han,
- Yuan Liu,
- Jinqi Deng,
- Yike Li,
- Xia Wu,
- Lili Cai,
- Lili Qin,
- Qinghua Chen,
- Yang Yuan,
- Yi Liu,
- Yulong Cong,
- Baoquan Ding,
- Zefei Jiang,
- Jiashu Sun
Affiliations
- Fei Tian
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Shaohua Zhang
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Chao Liu
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Ziwei Han
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yuan Liu
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Jinqi Deng
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yike Li
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Xia Wu
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Lili Cai
- Department of Laboratory Medicine, The Second Medical Center, Chinese PLA General Hospital
- Lili Qin
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Qinghua Chen
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Yang Yuan
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Yi Liu
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Yulong Cong
- Department of Laboratory Medicine, The Second Medical Center, Chinese PLA General Hospital
- Baoquan Ding
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Zefei Jiang
- Department of Breast Cancer, The Fifth Medical Centre, Chinese PLA General Hospital
- Jiashu Sun
- Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- DOI
- https://doi.org/10.1038/s41467-021-22913-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
A thermophoretic aptasensor can be used to profile cancer-associated proteins of extracellular vesicles (EVs) in patients’ plasma. Here, the authors use this technique to develop an EV-signature able to discriminate metastatic breast cancer, monitor treatment response, and predict patients’ progression-free survival.
