Preparation of poly (lactic-co-glycolic acid) microfiber membrane

Abstract

Poly (lactic-co-glycolic acid) (PLGA) is a kind of medical polymer material with good biodegradability and histocompatibility, which is widely used in postoperative anti-adhesion materials. In this paper, PLGA microfiber membrane was successfully prepared with poly(lactic-co-glycolic acid) as the main material by electrospinning technology. The surface morphology, wettability, dimensional stability and mechanical properties of PLGA microfiber films were characterized by scanning electron microscopy (SEM) and tensile testing machine. The results show that the average diameter of the prepared PLGA fiber is 2.218~2.313 μm, the elongation at break of the fiber film is up to 193%, and the dimensional stability and wettability of the fiber film are maintained at 37°C. The degradation cycle is 2~3 months.

Keywords

• electrospinning
• poly(lactic-co-glycolic acid)
• fiber diameter
• adhesion