Frontiers in Aging Neuroscience (Dec 2019)
Nodal Global Efficiency in Front-Parietal Lobe Mediated Periventricular White Matter Hyperintensity (PWMH)-Related Cognitive Impairment
- Haifeng Chen,
- Haifeng Chen,
- Haifeng Chen,
- Haifeng Chen,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Lili Huang,
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Dan Yang,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Qing Ye,
- Mengdi Guo,
- Mengdi Guo,
- Mengdi Guo,
- Mengdi Guo,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Ruomeng Qin,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Caimei Luo,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Mengchun Li,
- Lei Ye,
- Lei Ye,
- Lei Ye,
- Lei Ye,
- Bing Zhang,
- Yun Xu,
- Yun Xu,
- Yun Xu,
- Yun Xu
Affiliations
- Haifeng Chen
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Haifeng Chen
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Haifeng Chen
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Haifeng Chen
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Lili Huang
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Lili Huang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Lili Huang
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Dan Yang
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Dan Yang
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Dan Yang
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Qing Ye
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Qing Ye
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Qing Ye
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Qing Ye
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Mengdi Guo
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Mengdi Guo
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Mengdi Guo
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Mengdi Guo
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Ruomeng Qin
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Ruomeng Qin
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Ruomeng Qin
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Ruomeng Qin
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Caimei Luo
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Caimei Luo
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Caimei Luo
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Mengchun Li
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Mengchun Li
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Mengchun Li
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Lei Ye
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Lei Ye
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Lei Ye
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Lei Ye
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- Bing Zhang
- Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
- Yun Xu
- Department of Neurology, Drum Tower Hospital, Medical School and The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, China
- Yun Xu
- Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China
- Yun Xu
- Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China
- DOI
- https://doi.org/10.3389/fnagi.2019.00347
- Journal volume & issue
-
Vol. 11
Abstract
White matter hyperintensity (WMH) is widely observed in the elderly population and serves as a key indicator of cognitive impairment (CI). However, the underlying mechanism remains to be elucidated. Herein, we investigated the topological patterns of resting state functional networks in WMH subjects and the relationship between the topological measures and CI. A graph theory-based analysis was employed in the resting-state functional magnetic resonance scans of 112 subjects (38 WMH subjects with cognitive impairment without dementia (CIND), 36 WMH subjects with normal cognition and 38 healthy controls (HCs), and we found that WMH-CIND subjects displayed decreased global efficiency at the levels of the whole brain, specific subnetworks [fronto-parietal network (FPN) and cingulo-opercular network (CON)] and certain nodes located in the FPN and CON, as well as decreased local efficiency in subnetworks. Our results demonstrated that nodal global efficiency in frontal and parietal regions mediated the impairment of information processing speed related to periventricular WMH (PWMH). Additionally, we performed support vector machine (SVM) analysis and found that altered functional efficiency can identify WMH-CIND subjects with high accuracy, sensitivity and specificity. These findings suggest impaired functional networks in WMH-CIND individuals and that decreased functional efficiency may be a feature of CI in WMH subjects.
Keywords
- cognitive impairment
- cingulo-opercular network
- functional efficiency
- fronto-parietal network
- white matter hyperintensity
