Nature Communications (Jun 2018)
Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
- Serena Zacchigna,
- Valentina Martinelli,
- Silvia Moimas,
- Andrea Colliva,
- Marco Anzini,
- Andrea Nordio,
- Alessia Costa,
- Michael Rehman,
- Simone Vodret,
- Cristina Pierro,
- Giulia Colussi,
- Lorena Zentilin,
- Maria Ines Gutierrez,
- Ellen Dirkx,
- Carlin Long,
- Gianfranco Sinagra,
- David Klatzmann,
- Mauro Giacca
Affiliations
- Serena Zacchigna
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Valentina Martinelli
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Silvia Moimas
- Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy and Center for Translational Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste
- Andrea Colliva
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Marco Anzini
- Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy and Center for Translational Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste
- Andrea Nordio
- Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy and Center for Translational Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste
- Alessia Costa
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Michael Rehman
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Simone Vodret
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Cristina Pierro
- Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Giulia Colussi
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Lorena Zentilin
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Maria Ines Gutierrez
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Ellen Dirkx
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Carlin Long
- Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB)
- Gianfranco Sinagra
- Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy and Center for Translational Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste
- David Klatzmann
- Sorbonne Université, UPMC Univ Paris 06, INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (i3)
- Mauro Giacca
- Department of Medical, Surgical and Health Sciences, University of Trieste, 34127 Trieste, Italy and Center for Translational Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste
- DOI
- https://doi.org/10.1038/s41467-018-04908-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Regulatory T cells (Tregs) expand during pregnancy to promote tolerance towards the fetus. Here the authors show that Tregs induce proliferation of fetal and maternal cardiomyocytes during pregnancy and enhance myocardial repair via proliferation-promoting paracrine actions.
