Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

Hui-Ju Hsieh; Wei Zhang; Shu-Hong Lin; Wen-Hao Yang; Jun-Zhong Wang; Jianfeng Shen; Yiran Zhang; Yiling Lu; Hua Wang; Jane Yu; Gordon B. Mills; Guang Peng

doi:10.1038/s41467-018-05639-x

Nature Communications (Sep 2018)

Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

Hui-Ju Hsieh,
Wei Zhang,
Shu-Hong Lin,
Wen-Hao Yang,
Jun-Zhong Wang,
Jianfeng Shen,
Yiran Zhang,
Yiling Lu,
Hua Wang,
Jane Yu,
Gordon B. Mills,
Guang Peng

Affiliations

Hui-Ju Hsieh: Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
Wei Zhang: Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
Shu-Hong Lin: Department of Epidemiology, The University of Texas MD Anderson Cancer Center
Wen-Hao Yang: Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
Jun-Zhong Wang: Department of Electrical Engineering, National Kaohsiung University of Applied Sciences
Jianfeng Shen: Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center
Yiran Zhang: Department of Mathematical Sciences, Georgia Southern University
Yiling Lu: Department of Systems Biology, The University of Texas MD Anderson Cancer Center
Hua Wang: Department of Mathematical Sciences, Georgia Southern University
Jane Yu: Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine
Gordon B. Mills: Department of Systems Biology, The University of Texas MD Anderson Cancer Center
Guang Peng: Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s41467-018-05639-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cyclin B1 and PLK1 expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal