Thermosensitive hydrogel for in situ-controlled methotrexate delivery
Carrillo-Castillo Teresa Darlen,
Luna-Velasco Antonia,
Zaragoza-Contreras Erasto Armando,
Castro-Carmona Javier Servando
Affiliations
Carrillo-Castillo Teresa Darlen
Department of Engineering and Materials Chemistry, Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, C.P. 31136, Chihuahua, Chih, Mexico
Luna-Velasco Antonia
Department of Environment and Energy, Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, C.P. 31136, Chihuahua, Chih, Mexico
Zaragoza-Contreras Erasto Armando
Department of Engineering and Materials Chemistry, Centro de Investigación en Materiales Avanzados, S.C. Miguel de Cervantes No. 120, Complejo Industrial Chihuahua, C.P. 31136, Chihuahua, Chih, Mexico
Castro-Carmona Javier Servando
Engineering in Design and Agricultural/Food Automation, Universidad Autónoma de Ciudad Juárez, Manuel Díaz H. No. 518-B Zona Pronaf Condominio, C.P. 32315, Ciudad Juárez, Chih, Mexico
MTX is loaded and released in a controlled manner over 14 h, under physiological conditions, from an amphiphilic triblock copolymer with a sol–gel phase change at 36.5°C.
