Journal of Pain Research (Jul 2022)

Effect of Perioperative Intravenous Lidocaine on Postoperative Recovery in Patients Undergoing Ileostomy Closure: Study Protocol for a Randomized Controlled Trial

  • Liu J,
  • Liu K,
  • Wang H,
  • Hu H,
  • Sun G,
  • Ye X,
  • Lou Z,
  • Bian J,
  • Bo L

Journal volume & issue
Vol. Volume 15
pp. 1863 – 1872

Abstract

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Jia Liu,1,* Kun Liu,1,* Huixian Wang,1,* Hongli Hu,1 Guolin Sun,1 Xiaofei Ye,2 Zheng Lou,3 Jinjun Bian,1 Lulong Bo1 1Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Department of Health Statistics, Naval Medical University, Shanghai, People’s Republic of China; 3Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lulong Bo; Jinjun Bian, Faculty of Anaesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China, Tel +86-2131161839, Email [email protected]; [email protected]: Opioids have been widely used clinically as the first choice for pain management. Ileostomy closure usually leads to temporary intestinal paralysis, which manifests as abdominal distension and pain, delayed defecation, nausea, and vomiting. Intraoperative and postoperative use of opioids inhibit gastrointestinal function and aggravate intestinal paralysis, and are notoriously addictive. Thus, reducing perioperative opioid use is important for patients undergoing ileostomy closure to restore the continuity and integrity of the intestine. Intravenous lidocaine has been shown to have anti-inflammatory properties and analgesic effects. We consider minimizing the use of opioids for such patients, and perioperative intravenous injection of lidocaine may be beneficial to the recovery of intestinal function in patients with ileostomy closure.Methods and Analysis: This is a randomized double-blind placebo-controlled trial to investigate the effectiveness and safety of intravenous lidocaine in patients undergoing ileostomy closure. The time of first postoperative anal venting, postoperative opioids use, postoperative recovery, intraoperative adverse effects and postoperative complications will be collected and analyzed.Keywords: anesthesia, intravenous, lidocaine, ileostomy, recovery of function

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