Ecofriendly microwave-assisted preparation, characterization and antitumor activity of some propylimidazolium-based Ionic liquids derivatives

Abstract

An ecofriendly and efficient preparation of a set of a new 1-propylimidazolium-based ionic liquids (1–20) has been manufactured by using both microwave irradiation and conventional procedure. Different spectral analysis (FT-IR, mass spectra, NMR and elemental analysis) were utilized to examine the structures of the newly prepared ILs. The in vitro antitumor activities of all ILs (1–20) were investigated, using viability assay, towards HEPG-2, MCF7 and CACO2 Cells. Among all tested ILs, the 3-(3-phenylpropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (13) showed better activity towards human hepatocellular carcinoma (HEPG-2) and colon carcinoma (CACO2), while the 3-(3-phenoxypropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (20) exhibited low IC50 values against human breast adenocarcinoma (MCF7) compared to the standard drug (5-fluorouracil (5-FU)). Generally, all ILs 1–20 derivatives showed moderate cytotoxic activity against all tested cell lines.

Keywords

• green synthesis
• imidazolium
• ionic liquids
• toxicity
• microwave irradiation
• antitumor activity