UJI AKTIVITAS ANTIINFLAMASI KUERSETIN KULIT BAWANG MERAH (Allium cepa L.) PADA MENCIT PUTIH JANTAN (Mus musculus)

Abstract

Inflammation is a local reaction of infection or tissue injury and involves more mediators. Utilization of traditional medicine should be used to minimize the side effects of non-steroidal anti-inflammatory drugs, such as the use of onion skin (Allium cepa L.). This study aims to determine the activity of quercetin onion skin and the optimal dose of quercetin as a potential anti-inflammatory on male white mice. This study is an experimental research. Red onion skins extracted by maceration method. Preparation of the test is divided into five groups: control positive (Diclofenac Potassium 6,5mg/kg), control negative (Na-CMC), quercetin of onion skin dose I (50mg/kg), dose II (100mg/kg) and dose III (200mg/kg). Adduction of test compounds is given by oral, after 30 minute the right paw of mice induced by karagenin 1 %. Paw volume is analyzed with area under curve (AUC). The results showed that quercetin of onions skin have an anti-inflammatory activity. From the analyzed of AUC for each dose of quercetin showed anti-inflammatory power value for dose I amounted 57.13 %, dose II 59.08% , and dose III 73.75 % and ANOVA statistical test with p-value 0.005 ( < 0.05 ), which means there is a significant difference between control positive, dose I , and dose II with dose III, the optimal dose is dose III (200 mg / kg).

Keywords

• Anti-inflamation
• Allium cepa L.
• kuarsetin
• Area Under Curve