Silent or low expression of blaTEM and blaSHV suggests potential for targeted proteomics in clinical detection of β-lactamase-related antimicrobial resistance

• Huige Wu,
• Wenting Dong,
• Xinxin Hu,
• Chunyang Xie,
• Xinyi Yang,
• Congran Li,
• Guoqing Li,
• Yun Lu,
• Xuefu You

Affiliations

Huige Wu

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Wenting Dong

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Xinxin Hu

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Chunyang Xie

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Xinyi Yang

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Congran Li

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Guoqing Li

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Yun Lu

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Corresponding author. Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

Xuefu You

Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Division for Medicinal Microorganisms-Related Strains, CAMS Collection Center of Pathogenic Microorganisms, Beijing, 100050, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Corresponding author. Beijing Key Laboratory of Technology and Application for Anti-Infection New Drugs Research and Development/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China