Human disordered charged biased proteins: from the proteome to the druggome

Abstract

The human disordered charged biased proteins (HDCBPs) are involved in complex diseases. The HDCBP-disease network constructed in our earlier showed that HDCBPs share many diseases. Therefore, they are attractive therapeutic targets for drug discovery. In this study, we explore the associations between (HDCBPs), the related diseases, and the drugs. The results show that 20% and 14% of HDCBPs are listed in DRUGBANK and ChemDB respectively. The elaborated HDCBP-Drug-Disease network revealed that most of the therapeutic area indications included cancer, neoplasm, lymphoma, cardiovascular, respiratory and skin diseases. The constructed HDCBP-Drug-Disease network may improve our understanding of complex diseases and related drugs. Moreover, such a network could suggest opportunities of drug repurposing for which efficacy should be investigated in functional validation studies.

Keywords

• charged biased proteins
• diseases
• databases
• drugs
• network
• therapeutic targets