Advanced Science (Mar 2024)
Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age‐Related Cognitive Dysfunction
- Peter Mukli,
- Camila B. Pinto,
- Cameron D. Owens,
- Tamas Csipo,
- Agnes Lipecz,
- Zsofia Szarvas,
- Anna Peterfi,
- Ana Clara da Costa Pinaffi Langley,
- Jordan Hoffmeister,
- Frigyes Samuel Racz,
- Jonathan W. Perry,
- Stefano Tarantini,
- Ádám Nyúl‐Tóth,
- Farzaneh A. Sorond,
- Yuan Yang,
- Judith A. James,
- Angelia C. Kirkpatrick,
- Calin I. Prodan,
- Peter Toth,
- Juliette Galindo,
- Andrew W. Gardner,
- William E. Sonntag,
- Anna Csiszar,
- Zoltan Ungvari,
- Andriy Yabluchanskiy
Affiliations
- Peter Mukli
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Camila B. Pinto
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Cameron D. Owens
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Tamas Csipo
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Agnes Lipecz
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Zsofia Szarvas
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Anna Peterfi
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Ana Clara da Costa Pinaffi Langley
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Jordan Hoffmeister
- Department of Cardiology Division of Clinical Physiology Faculty of Medicine University of Debrecen Debrecen H‐4032 Hungary
- Frigyes Samuel Racz
- Department of Physiology Faculty of Medicine Semmelweis University Budapest H‐1094 Hungary
- Jonathan W. Perry
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Stefano Tarantini
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Ádám Nyúl‐Tóth
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Farzaneh A. Sorond
- Department of Neurology Division of Stroke and Neurocritical Care Northwestern University Feinberg School of Medicine 303 E. Chicago Ave. Chicago IL 60611 USA
- Yuan Yang
- Stephenson School of Biomedical Engineering The University of Oklahoma Tulsa OK 73019 USA
- Judith A. James
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Angelia C. Kirkpatrick
- Veterans Affairs Medical Center Oklahoma City OK 73104 USA
- Calin I. Prodan
- Veterans Affairs Medical Center Oklahoma City OK 73104 USA
- Peter Toth
- International Training Program in Geroscience Doctoral School of Basic and Translational Medicine/Department of Public Health Semmelweis University Budapest H‐1085 Hungary
- Juliette Galindo
- Department of Cardiology Division of Clinical Physiology Faculty of Medicine University of Debrecen Debrecen H‐4032 Hungary
- Andrew W. Gardner
- Department of Physical Medicine and Rehabilitation Penn State College of Medicine 700 HMC Crescent Road Hershey PA 17033 USA
- William E. Sonntag
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Anna Csiszar
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Zoltan Ungvari
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- Andriy Yabluchanskiy
- Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA
- DOI
- https://doi.org/10.1002/advs.202303516
- Journal volume & issue
-
Vol. 11,
no. 10
pp. n/a – n/a
Abstract
Abstract Impaired cerebrovascular function contributes to the genesis of age‐related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n‐back) paradigm, oxy‐ and deoxyhemoglobin concentration changes from the frontal cortex using functional near‐infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2‐back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age‐related decline in accuracy during the 2‐back task. These findings suggest that task‐related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.
Keywords
- aging
- cognitive decline
- functional connectivity
- functional near‐infrared spectroscopy
- neurovascular coupling
