Regulatory T-cells CD4+CD25+Foxр3+ in patients with remitting multiple sclerosis

Abstract

In the maintenance of immunological tolerance a recently discoveredpopulation of regulatory T-cells CD4+CD25+Foxp3+(Treg) plays an important role. These cells have potential in suppressingpathologic immune response observed in variousautoimmune diseases, including multiple sclerosis. In the presentwork, we showed reduction in the number and functionalactivity of Treg in peripheral blood of patients with multiple sclerosisin the acute stage, as well as increase in Treg content in thedisease remission and relation of the Treg content with durationof the autoimmune process and the degree of disability ofpatients.

Keywords

• multiple sclerosis
• pathogenesis
• regulatory t-cells