The deregulation of arachidonic acid metabolism in ovarian cancer

Qiuyi Xia; Wen Gao; Jintao Yang; Zhifang Xing; Zhaodong Ji

doi:10.3389/fonc.2024.1381894

Frontiers in Oncology (May 2024)

The deregulation of arachidonic acid metabolism in ovarian cancer

Qiuyi Xia,
Wen Gao,
Jintao Yang,
Zhifang Xing,
Zhaodong Ji

Affiliations

Qiuyi Xia: Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China
Wen Gao: Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China
Jintao Yang: Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Hangzhou, Zhejiang, China
Zhifang Xing: Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China
Zhaodong Ji: Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2024.1381894
Journal volume & issue: Vol. 14

Abstract

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Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent studies have indicated that AA and its metabolites play significant regulatory roles in the onset and progression of ovarian cancer. This article examines the recent research advancements on the correlation between AA metabolites and ovarian cancer, both domestically and internationally, suggesting their potential use as biological markers for early diagnosis, targeted therapy, and prognosis monitoring.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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